BIODERMA
Development of an innovative anti-psoriasis treatment and testing in a
biotechnological substitute for healthy and psoriatic human skin
T1EDK-03798
with the co-funding of Greece and European Union
OBJECTIVE
Development of a new, biotechnological full-thickness skin replacement as a 3D in vitro model of healthy skin study, as well as skin model with psoriasis and production of new therapeutic products for its more effective treatment
About 2% of the world's population suffers from psoriasis and needs to resort to treatments to deal with it. Psoriasis is a complex immune-related skin disorder, without clear etiology or healing.
When a drug is intended for humans, the best way to evaluate it is to do in vivo test in humans. This is not always feasible, especially when the medicine is at an early stage of assessment. In vitro models of human artificial skin are increasingly coming to the forefront for corresponding studies. Although these models are quite successful and represent the histological structure of normal skin, they show increased transdermal permeability which makes them unsuitable for drug absorption testing.
The biotechnology company BIOHELLENIKA, with years of experience in stem cell and research on cellular therapies and modern equipment at its premises, and the team of Professor Bikiaris, with the necessary experience and appropriate laboratory equipment for biomimetic synthesis of extracellular matrix are working together to:
1. Develop strategies for creating a new artificial skin model composed of epidermis and dermis, with improved epidermal barrier by improving epidermal differentiation;
2. Develop a model of psoriatic artificial skin; and
3. Asses the action of new polymer-based patches with embedded biological agents or a combination thereof for the treatment of psoriasis.
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Project Coordination: BIOHELLENIKA (Dr. George Koliakos)
Principal Investigator: Prof Dimitrios Bikiaris
Duration: 28/06/2018-27/06/2022
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Publications in international scientific journals
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Preparation and Evaluation of Collagen-Based Patches as Curcumin Carriers
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Preliminary Evaluation of 3D Printed Chitosan/Pectin Constructs for Biomedical Applications
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Altered Distribution and Expression of Syndecan-1 and -4 as an Additional Hallmark in Psoriasis
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Poster presentations in international conferences
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Nina-Maria Ainali, Zoi Terzopoulou, Artemis Palamidi, Anna Michopoulou, Dimitrios Bikiaris. Collagen based scaffolds for improved topical therapeutic effect on psoriasis. European Polymer Congress 2019, Hersonissos Heraklion Crete, Greece, June 9-14, 2019
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Dimitrios Bikiaris, Zoi Terzopoulou, Anna Michopoulou, Artemis Palamidi, Eleni Pavlidou. Effect of covalent heparin immobilization on the properties of collagen scaffolds. 7th International Conference on Biobased and Biodegradable Polymers. Stockholm, Sweden, June 17-19, 2019.
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Zoi Terzopoulou, Anna Michopoulou, Artemis Palamidi, Dimitrios Bikiaris. Collagen-based scaffolds loaded with curcumin for the treatment of psoriasis. 7th International Conference on Biobased and Biodegradable Polymers. Stockholm, Sweden, June 17-19, 2019.
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Anna Michopoulou, Z. Terzopoulou, E. Gounari, E. Koliakou, P. Rousselle, K. Kouzi. Impact of papillary or reticular fibroblasts on dermal-epidermal homeostasis in a skin equivalent model. ETRS Annual Scientific Meeting, Tissue regeneration – “From basic science to clinical translation”, September 11-13 2019, Munich, Germany.
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Z. Terzopoulou, A. Michopoulou, A. Palamidi, D. Bikiaris. Preparation and characterization of curcumin-loaded chitosan nanoparticles incorporated in collagen scaffolds for the transdermal treatment of psoriasis. Polymer Processing 4.0 “Europe-Africa PPS2019”, 18-21 November 2019, Pretoria, South Africa.
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