We are very happy to share the latest publications of our group. The topics of the publications include preparation of drug delivery systems, 3D printing of polysaccharides and investigation of the molecular mobility of PLA nanocomposite materials.
Novel 3D-Printed Dressings of Chitosan–Vanillin-Modified Chitosan Blends Loaded with Fluticasone Propionate for Treatment of Atopic Dermatitis
The paper "Novel 3D-Printed Dressings of Chitosan–Vanillin-Modified Chitosan Blends Loaded with Fluticasone Propionate for Treatment of Atopic Dermatitis" was published in Pharmaceutics (IF 6.072). The main objective of the publication is the preparation of patches through the 3D printing of chitosan blends via a bioprinter, for the administration fluticasone propionate. The prepared blends revealed appropriate viscosity values for extrusion through a 3D printer while the 3D-printed samples were able to maintain their shape after printing and crosslinking procedures. Moreover, enhanced release of fluticasone propionate renders the 3D-printed samples potential candidates for the treatment of atopic dermatitis.
The implementation of the doctoral thesis was co-financed by Greece and the European Union (European Social Fund-ESF) through the Operational Programme “Human Resources Devel- opment, Education and Lifelong Learning” in the context of the Act “Enhancing Human Resources Research Potential by undertaking a Doctoral Research” Sub-action 2: IKY Scholarship Programme for PhD candidates in the Greek Universities.
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L-Cysteine Modified Chitosan Nanoparticles and Carbon-Based Nanostructures for the Intranasal Delivery of Galantamine
The paper entitled "L-Cysteine Modified Chitosan Nanoparticles and Carbon-Based Nanostructures for the Intranasal Delivery of Galantamine" was published in Polymers (IF 4.967). The principal goal of the publication was the intranasal administration of galantamine through nanoparticles of a cystein-chitosan derivative with incorporated new carbon-based materials. The use of the new derivative led to a significant solubility enhancement in neutral and alkaline pH values, improving chitosan’s utility as a matrix carrier for intranasal drug formulations, while the use of carbon-based materials led to the formation of a thermodynamically stable drug dispersion with a zero-order release profile.
This project has received funding from the Hellenic Foundation for Research and Innovation (HFRI) and the General Secretariat for Research and Technology (GSRT), under grant agreement No [1914].
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Thermal transitions, interfacial interactions, and molecular mobility in nanocomposites based on poly(l,d-lactic acid) and fumed silica nanoparticles
The paper entitled "Thermal transitions, interfacial interactions, and molecular mobility in nanocomposites based on poly(l,d-lactic acid) and fumed silica nanoparticles" was published in Journal of thermal analysis and calorimetry (IF 4.626). The topic of the publication was the investigation of the direct and indirect effects of silica nanoparticles, on the molecular mobility and crystallization of a series of polymer nanocomposites, based on polylactide, PLA. The interfacial interactions between the fillers and the polymeric matrix of the nanocomposites were manifested between the surface -OH and the PLA backbone -C=O.
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